Evidence and Potential Antibacterial Mechanism of Chinese Traditional Medicine Compounds for the Development of <i>E. coli</i>

Astragalus membranaceus (huangqi), Allium sativum (garlic), Cinnamomum cassia (cinnamon), and Dolichos lablab L. (white hyacinth bean) are the traditional Chinese herbs that were used in prescriptions treating diarrhea caused by bacterial infection. These relatively safe for use investigation. This study aimed to investigate effects of membranaceus, sativum, cassia, on metabolism Escherichia coli (E. coli). The growth rate E. was monitored under influence each herb, revealing exhibited significant antibacterial activity, whereas demonstrated moderate inhibitory growth. Further inhibition zone testing allowed evaluation herb’s potency number generations required develop resistance. Additionally, impact four expression outer membrane protein A (OmpA) examined using qPCR. findings revealed acted as a sustainable bactericide inhibiting MG1655 through suppression OmpA expression. results suggest has potential natural antimicrobial agent infections.